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Structural basis for 5'-end-specific recognition of single-stranded DNA by the R3H domain from human Sμbp-2

Jaudzems, Kristaps; Jia, Xinying; Yagi, Hiromasa; Zhulenkovs, Dmitry; Graham, Bim; Otting, Gottfried; Liepinsh, Edvards


The R3H domain is a conserved sequence motif in nucleic acid binding proteins. Previously, we reported the solution structure of the R3H domain and identified a putative nucleic acid binding site composed of three conserved basic residues [Liepinsh, E., Leonchiks, A., Sharipo, A., Guignard, L. & Otting, G. (2003). Solution structure of the R3H domain from human Sμbp-2. J. Mol. Biol. 326, 217-223]. Here, we determine the binding affinities of mononucleotides and dinucleotides for the R3H domain...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Journal of Molecular Biology
DOI: 10.1016/j.jmb.2012.09.010


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