IFNL3 genotype is associated with pulmonary fibrosis in patients with systemic sclerosis
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Metwally, Mayada; Thabet, Khaled; Bayoumi, Ali; Nikpour, Mandana; Stevens, Wendy M; Sahhar, Joanne; Zochling, Jane; Roddy, J.; Tymms, Kathleen; Strickland, G; Lester, Susan; Rischmueller, Maureen; Ngian, Gene Siew; Walker, Jennifer; Hissaria, Pravin; Shaker, Olfat; Liddle, Christopher; Manolios, Nicholas; Beretta, Lorenzo; Proudman, Susanna M.; George, Jacob; Eslam, Mohammed
Description
Fibrosis across different organs and tissues is likely to share common pathophysiological mechanisms and pathways. Recently, a polymorphism (rs12979860) near the interferon lambda gene (IFNL3) was shown to be associated with fibrosis in liver across multiple disease etiologies. We determined whether this variant is a risk factor for pulmonary fibrosis (PF) and worsening cutaneous fibrosis in systemic sclerosis (SSc). Caucasian patients with SSc (n = 733) were genotyped to test for association...[Show more]
Collections | ANU Research Publications |
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Date published: | 2019 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/219971 |
Source: | Scientific Reports |
DOI: | 10.1038/s41598-019-50709-9 |
Access Rights: | Open Access |
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01_Metwally_IFNL3_genotype_is_associated_2019.pdf | 882.83 kB | Adobe PDF |
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