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Molecular mechanisms activating the NAIP‐NLRC4 inflammasome: Implications in infectious disease, autoinflammation, and cancer

Kay, Callum; Wang, Runli; Kirkby, Max; Man, Si Ming


Cytosolic innate immune sensing is a cornerstone of innate immunity in mammalian cells and provides a surveillance system for invading pathogens and endogenous danger signals. The NAIP‐NLRC4 inflammasome responds to cytosolic flagellin, and the inner rod and needle proteins of the type 3 secretion system of bacteria. This complex induces caspase‐1‐dependent proteolytic cleavage of the proinflammatory cytokines IL‐1β and IL‐18, and the pore‐forming protein gasdermin D, leading to inflammation...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
Source: Immunological Reviews
DOI: 10.1111/imr.12906
Access Rights: Open Access


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