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Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome

Fox, Daniel; Mathur, Anukriti; Xue, Yansong; Liu, Yunqi; Tan, Wei Hong; Feng, Shouya; Pandey, Abhimanu; Ngo, Chinh; Hayward, Jenni; Atmosukarto, Ines; Price, Jason; johnson, matthew; Jessberger, Nadja; Robertson, Avril; Burgio, Gaetan; Tscharke, David; Fox, Edward M; Leyton, Denisse; Kaakoush, Nadeem; Märtlbauer, Erwin; Leppla, Stephen H; Man, Si Ming


Inflammasomes are important for host defence against pathogens and homeostasis with commensal microbes. Here, we show non-haemolytic enterotoxin (NHE) from the neglected human foodborne pathogen Bacillus cereus is an activator of the NLRP3 inflammasome and pyroptosis. NHE is a non-redundant toxin to haemolysin BL (HBL) despite having a similar mechanism of action. Via a putative transmembrane region, subunit C of NHE initiates binding to the plasma membrane, leading to the recruitment of...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
Source: Nature Communications
DOI: 10.1038/s41467-020-14534-3
Access Rights: Open Access


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