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Fibrin exposure triggers αIIbβ3-independent platelet aggregate formation, ADAM10 activity and glycoprotein VI shedding in a charge-dependent manner

Montague, Samantha; Hicks, Sarah; Lee, Christine; Coupland, Lucy; Parish, Christopher; Lee, W M Steve; Andrews, Robert; Gardiner, Elizabeth


Background Collagen and fibrin engagement and activation of glycoprotein (GP) VI induces proteolytic cleavage of the GPVI ectodomain generating shed soluble GPVI (sGPVI). Collagen‐mediated GPVI shedding requires intracellular signalling to release the sGPVI, mediated by A Disintegrin And Metalloproteinase 10 (ADAM10); however, the precise mechanism by which fibrin induces GPVI shedding remains elusive. Plasma sGPVI levels are elevated in patients with coagulopathies, sepsis, or inflammation...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
Source: Journal of Thrombosis and Haemostasis
DOI: 10.1111/jth.14797


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