A Total Synthesis of (±)-3-O-Demethylmacronine through Rearrangement of a Precursor Embodying the Haemanthidine Alkaloid Framework
A total synthesis of the racemic modification, (±)-2, of the tazettine-type alkaloid 3-O-demethylmacronine is described. The key steps are an intramolecular Alder-ene (IMAE) reaction and a lactam-to-lactone rearrangement of tetracycle 13, a compound that embodies the haemanthidine alkaloid framework.
|Collections||ANU Research Publications|
|Source:||Journal of Organic Chemistry|
|Access Rights:||Open Access|
|Total Synthesis of (±)-3-O-Demethylmacronine R1.pdf||332.46 kB||Adobe PDF|
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