In search of radical intermediates in the reactions catalyzed by lysine 2,3-aminomutase and lysine 5,6-aminomutase
-
Altmetric Citations
Sandala, Gregory; Smith, David M; Radom, Leo
Description
High-level ab initio calculations have been used to study radical intermediates in the reactions catalyzed by lysine 2,3-aminomutase (2,3-LAM) and lysine 5,6-aminomutase (5,6-LAM). The reactions of these enzymes with the substrate analogues 4-oxalysine (4-OL), 4-thialysine (4-TL), or trans-4,5-dehydrolysine (t-4,5-DL) are rationalized in terms of stabilization provided by the substituent to the adjacent radical center. Large changes in the exothermicity accompanying the initial H-abstraction...[Show more]
Collections | ANU Research Publications |
---|---|
Date published: | 2006 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/21883 |
Source: | Journal of the American Chemical Society |
DOI: | 10.1021/ja0668421 |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_Sandala_In_search_of_radical_2006.pdf | 389.24 kB | Adobe PDF | Request a copy |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator