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Successful treatment of PD peritonitis due to brevundimonas vesicularis

Christiadi, D; Singer, Richard; Roberts, Darren

Description

Brevundimonas vesicularis is a rare cause of peritoneal dialysis-associated peritonitis (PD peritonitis). One documented case report described poor outcome despite treatment with appropriate antibiotics. Here, we report the successful treatment of PD peritonitis due to Brevundimonas vesicularis with 21 days of intraperitoneal (IP) antibiotics using the regimen described for Pseudomonas aeruginosa, notably IP gentamicin (10 days) followed by IP cefepime and oral ciprofloxacin (11 days). Despite...[Show more]

dc.contributor.authorChristiadi, D
dc.contributor.authorSinger, Richard
dc.contributor.authorRoberts, Darren
dc.date.accessioned2020-12-20T20:58:57Z
dc.date.available2020-12-20T20:58:57Z
dc.identifier.issn0896-8608
dc.identifier.urihttp://hdl.handle.net/1885/218767
dc.description.abstractBrevundimonas vesicularis is a rare cause of peritoneal dialysis-associated peritonitis (PD peritonitis). One documented case report described poor outcome despite treatment with appropriate antibiotics. Here, we report the successful treatment of PD peritonitis due to Brevundimonas vesicularis with 21 days of intraperitoneal (IP) antibiotics using the regimen described for Pseudomonas aeruginosa, notably IP gentamicin (10 days) followed by IP cefepime and oral ciprofloxacin (11 days). Despite the favorable outcome, measurement of antibiotic concentrations in the PD effluent suggests that the cefepime and possibly ciprofloxacin regimens do not achieve key antibiotic concentration targets that are reported to maximize bacterial kill. The role of routine therapeutic drug monitoring to maximize clinical outcomes from antibiotic therapy for PD peritonitis requires further consideration.
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherMultimed, Inc.
dc.sourcePeritoneal Dialysis International
dc.titleSuccessful treatment of PD peritonitis due to brevundimonas vesicularis
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume38
dc.date.issued2018
local.identifier.absfor110312 - Nephrology and Urology
local.identifier.ariespublicationu4485658xPUB121
local.type.statusPublished Version
local.contributor.affiliationChristiadi, D, The Canberra Hospital
local.contributor.affiliationSinger, Richard, College of Health and Medicine, ANU
local.contributor.affiliationRoberts, Darren, College of Health and Medicine, ANU
local.bibliographicCitation.issue5
local.identifier.doi10.3747/pdi.2018.00014
local.identifier.absseo920106 - Endocrine Organs and Diseases (excl. Diabetes)
dc.date.updated2020-12-13T07:27:36Z
local.identifier.scopusID2-s2.0-85053086104
CollectionsANU Research Publications

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