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Voltage-Gated Sodium Channel Pharmacology: Insights From Molecular Dynamics Simulations

Chen, Rong; Buyan, Amanda; Corry, Ben

Description

Voltage-gated ion channels are the target of a range of naturally occurring toxins and therapeutic drugs. There is a great interest in better understanding how these diverse compounds alter channel function in order to design the next generation of therapeutics that can selectively target one of the channel subtypes found in the body. Since the publication of a number of bacterial sodium channel structures, molecular dynamics simulations have been invaluable in gaining a high resolution...[Show more]

dc.contributor.authorChen, Rong
dc.contributor.authorBuyan, Amanda
dc.contributor.authorCorry, Ben
dc.date.accessioned2020-12-20T20:58:29Z
dc.date.available2020-12-20T20:58:29Z
dc.identifier.issn1054-3589
dc.identifier.urihttp://hdl.handle.net/1885/218606
dc.description.abstractVoltage-gated ion channels are the target of a range of naturally occurring toxins and therapeutic drugs. There is a great interest in better understanding how these diverse compounds alter channel function in order to design the next generation of therapeutics that can selectively target one of the channel subtypes found in the body. Since the publication of a number of bacterial sodium channel structures, molecular dynamics simulations have been invaluable in gaining a high resolution understanding where many of these small molecules and toxins bind to the channels, how they find their binding site, and how they can selectively bind to one channel subtype over another. This chapter summarizes these recent studies to highlight what has been learnt about channel pharmacology using computer simulations and to draw out shared conclusions, focusing separately on toxin–channel interactions and small molecule–channel interactions
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherAcademic Press
dc.sourceAdvances in Pharmacology
dc.titleVoltage-Gated Sodium Channel Pharmacology: Insights From Molecular Dynamics Simulations
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume79
dc.date.issued2017
local.identifier.absfor111500 - PHARMACOLOGY AND PHARMACEUTICAL SCIENCES
local.identifier.ariespublicationa383154xPUB8532
local.type.statusPublished Version
local.contributor.affiliationChen, Rong, College of Science, ANU
local.contributor.affiliationBuyan, Amanda, College of Science, ANU
local.contributor.affiliationCorry, Ben, College of Science, ANU
local.identifier.doi10.1016/bs.apha.2017.02.002
dc.date.updated2020-11-23T11:26:59Z
local.identifier.scopusID2-s2.0-85016392716
local.identifier.thomsonIDMEDLINE:28528671
CollectionsANU Research Publications

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