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Voltage-Gated Sodium Channel Pharmacology: Insights From Molecular Dynamics Simulations

Chen, Rong; Buyan, Amanda; Corry, Ben

Description

Voltage-gated ion channels are the target of a range of naturally occurring toxins and therapeutic drugs. There is a great interest in better understanding how these diverse compounds alter channel function in order to design the next generation of therapeutics that can selectively target one of the channel subtypes found in the body. Since the publication of a number of bacterial sodium channel structures, molecular dynamics simulations have been invaluable in gaining a high resolution...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/218606
Source: Advances in Pharmacology
DOI: 10.1016/bs.apha.2017.02.002

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