The growing world of small heat shock proteins: from structure to functions
Carra, Serena; Alberti, Simon; Arrigo, Patrick A.; Benesch, Justin L. P.; Benjamin, Ivor J.; Boelens, Wilbert C.; Bartelt-Kirbach, Britta; Brundel, Bianca J.J.M.; Buchner, Johannes; Bukau, Bernd; Carver, John
Small heat shock proteins (sHSPs) are present in all kingdoms of life and play fundamental roles in cell biology. sHSPs are key components of the cellular protein quality control system, acting as the first line of defense against conditions that affect protein homeostasis and proteome stability,from bacteria to plants to humans. sHSPs have the ability to bind to a large subset of substrates and to maintain them in a state competent for refolding or clearance with the assistance of the HSP70...[Show more]
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