Retinal metabolic events in preconditioning light stress as revealed by wide-spectrum targeted metabolomics
Introduction: Light is the primary stimulus for vision, but may also cause damage to the retina. Pre-exposing the retina to sub-lethal amount of light (or preconditioning) improves chances for retinal cells to survive acute damaging light stress. Objectives: This study aims at exploring the changes in retinal metabolome after mild light stress and identifying mechanisms that may be involved in preconditioning. Methods: Retinas from 12 rats exposed to mild light stress (1000 lux × for 12 h) and...[Show more]
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