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Retinal metabolic events in preconditioning light stress as revealed by wide-spectrum targeted metabolomics

Chao De La Barca, Juan; Huang, Nuan-Ting; Jiao, Haihan; Tessier, Lydie; Gadras, Cédric; Simard, Gilles; Natoli, Riccardo; Tcherkez, Guillaume; Reynier, Pascal; Valter, Krisztina

Description

Introduction: Light is the primary stimulus for vision, but may also cause damage to the retina. Pre-exposing the retina to sub-lethal amount of light (or preconditioning) improves chances for retinal cells to survive acute damaging light stress. Objectives: This study aims at exploring the changes in retinal metabolome after mild light stress and identifying mechanisms that may be involved in preconditioning. Methods: Retinas from 12 rats exposed to mild light stress (1000 lux × for 12 h) and...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/218371
Source: Metabolomics
DOI: 10.1007/s11306-016-1156-9

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