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Physiology and Pharmacology of Ryanodine Receptor Calcium Release Channels

Dulhunty, Angela; Board, Philip; Beard, Nicole; Casarotto, Marco

Description

Ryanodine receptor (RyR) ion channels are essential for skeletal and cardiac muscle function. Their knockout leads to perinatal death from respiratory and cardiac failure. Acquired changes or mutations in the protein cause debilitating skeletal myopathy and cardiac arrhythmia which can be deadly. Knowledge of the pharmacology of RyR channels is central to developing effective and specific treatments of these myopathies. The ion channel is a >2.2MDa homotetamer with distinct structural and...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/218310
Source: Advances in Pharmacology
DOI: 10.1016/bs.apha.2016.12.001

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