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NK cell heparanase controls tumor invasion and immune surveillance

Putz, Eva M; Mayfosh, Alyce J; Kos, Kevin; Barkauskas, Deborah S; Nakamura, Kyohei; Town, Liam; Goodall, Katherine J.; Yee, Dean; Poon, Ivan K.A.; Baschuk, Nikola; Souza-Fonseca-Guimaraes, Fernando; Hulett, Mark; Smyth, Mark J

Description

NK cells are highly efficient at preventing cancer metastasis but are infrequently found in the core of primary tumors. Here, have we demonstrated that freshly isolated mouse and human NK cells express low levels of the endo-β-D-glucuronidase heparanase that increase upon NK cell activation. Heparanase deficiency did not affect development, differentiation, or tissue localization of NK cells under steady-state conditions. However, mice lacking heparanase specifically in NK cells (Hpsefl/fl...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/218260
Source: Journal of Clinical Investigation
DOI: 10.1172/JCI92958

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