Mycobacterial F420H2-dependent reductases promiscuously reduce diverse compounds through a common mechanism
Greening, Chris; Thanavit, Jirapanjawat; Shahana, Afroze; Ney, Blair; Scott, Colin; Pandey, Gunjan; Lee, Brendon; Russell, Robyn; Jackson, Colin; Oakeshott, J. G.; Taylor, Matthew C.; Warden, Andrew C.
An unusual aspect of actinobacterial metabolism is the use of the redox cofactor F420. Studies have shown that actinobacterial F420H2-dependent reductases promiscuously hydrogenate diverse organic compounds in biodegradative and biosynthetic processes. These enzymes therefore represent promising candidates for next-generation industrial biocatalysts. In this work, we undertook the first broad survey of these enzymes as potential industrial biocatalysts by exploring the extent, as well as...[Show more]
|Collections||ANU Research Publications|
|Source:||Frontiers in Microbiology|
|Access Rights:||Open Access|
|fmicb-08-01000.pdf||1.98 MB||Adobe PDF|
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