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Mycobacterial F420H2-dependent reductases promiscuously reduce diverse compounds through a common mechanism

Greening, Chris; Thanavit, Jirapanjawat; Shahana, Afroze; Ney, Blair; Scott, Colin; Pandey, Gunjan; Lee, Brendon; Russell, Robyn; Jackson, Colin; Oakeshott, J. G.; Taylor, Matthew C.; Warden, Andrew C.


An unusual aspect of actinobacterial metabolism is the use of the redox cofactor F420. Studies have shown that actinobacterial F420H2-dependent reductases promiscuously hydrogenate diverse organic compounds in biodegradative and biosynthetic processes. These enzymes therefore represent promising candidates for next-generation industrial biocatalysts. In this work, we undertook the first broad survey of these enzymes as potential industrial biocatalysts by exploring the extent, as well as...[Show more]

CollectionsANU Research Publications
Date published: 2017-05-31
Type: Journal article
Source: Frontiers in Microbiology
DOI: 10.3389/fmicb.2017.01000
Access Rights: Open Access


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