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Mechanisms and functions of guanylate-binding proteins: roles in intracellular lysis of pathogens

Ngo, Chinh; Man, Si Ming

Description

Guanylate-binding proteins (GBPs) are a group interferon-inducible GTPases within the constellation of the dynamin GTPase superfamily. These proteins restrict the replication of intracellular pathogens in both immune and non-immune cells. GBPs and their related family members immunity-related GTPases target and lyse the membrane of the pathogen-containing vacuole, destroying the residential niche of vacuolar protozoal and bacterial pathogens. They also prevent virion infectivity and target...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/218220
Source: Cellular Microbiology
DOI: 10.1111/cmi.12791

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