Skip navigation
Skip navigation

Frequency of Cancer Genes on the Chicken Z Chromosome and its Human Homologues: Implications for Sex Chromosome Evolution

Stiglec, Rami; Kohn, Matthias; Fong, James; Ezaz, Tariq; Hameister, Horst; Graves, Jennifer


It has been suggested that there are special evolutionary forces that act on sex chromosomes. Hemizygosity of the X chromosome in male mammals has led to selection for male-advantage genes, and against genes posing extreme risks of tumor development. A similar bias against cancer genes should also apply to the Z chromosome that is present as a single copy in female birds. Using comparative database analysis, we found that there was no significant underrepresentation of cancer genes on the...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Comparative and Functional Genomics
DOI: 10.1155/2007/43070


File Description SizeFormat Image
01_Stiglec_Frequency_of_Cancer_Genes_on_2007.pdf697.9 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator