Frequency of Cancer Genes on the Chicken Z Chromosome and its Human Homologues: Implications for Sex Chromosome Evolution
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Stiglec, Rami; Kohn, Matthias; Fong, James; Ezaz, Tariq; Hameister, Horst; Graves, Jennifer
Description
It has been suggested that there are special evolutionary forces that act on sex chromosomes. Hemizygosity of the X chromosome in male mammals has led to selection for male-advantage genes, and against genes posing extreme risks of tumor development. A similar bias against cancer genes should also apply to the Z chromosome that is present as a single copy in female birds. Using comparative database analysis, we found that there was no significant underrepresentation of cancer genes on the...[Show more]
Collections | ANU Research Publications |
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Date published: | 2007 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/21817 |
Source: | Comparative and Functional Genomics |
DOI: | 10.1155/2007/43070 |
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01_Stiglec_Frequency_of_Cancer_Genes_on_2007.pdf | 697.9 kB | Adobe PDF | Request a copy |
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