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Frequency of Cancer Genes on the Chicken Z Chromosome and its Human Homologues: Implications for Sex Chromosome Evolution

Stiglec, Rami; Kohn, Matthias; Fong, James; Ezaz, Tariq; Hameister, Horst; Graves, Jennifer

Description

It has been suggested that there are special evolutionary forces that act on sex chromosomes. Hemizygosity of the X chromosome in male mammals has led to selection for male-advantage genes, and against genes posing extreme risks of tumor development. A similar bias against cancer genes should also apply to the Z chromosome that is present as a single copy in female birds. Using comparative database analysis, we found that there was no significant underrepresentation of cancer genes on the...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
URI: http://hdl.handle.net/1885/21817
Source: Comparative and Functional Genomics
DOI: 10.1155/2007/43070

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