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High resolution crystal structure of a fluoride-inhibited organophosphate-degrading metallohydrolase

Selleck, Christopher; Guddat, Luke; Ollis, David; Schenk, Gerhard; Pedroso, Marcelo M


Metal ion-dependent, organophosphate-degrading enzymes (OP hydrolases) have received increasing attention due to their ability to degrade and thus detoxify commonly used pesticides and nerve agents such as sarin and VX. These enzymes thus garner strong potential as bioremediators. The OP hydrolase from Agrobacterium radiobacter (OpdA) is one of the most efficient members of this group of enzymes. Previous studies have indicated that the choice of the hydrolysis-initiating nucleophile may depend...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Journal of Inorganic Biochemistry
DOI: 10.1016/j.jinorgbio.2017.06.013


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