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Extracellular histones induce erythrocyte fragility and anemia

Kordbacheh, Farzaneh; O'Meara, Connor; Coupland, Lucy; Lelliott, Patrick; Parish, Christopher

Description

Extracellular histones have been shown to play an important pathogenic role in many diseases, primarily through their cytotoxicity towards nucleated cells and their ability to promote platelet activation with resultant thrombosis and thrombocytopenia. In contrast, little is known about the effect of extracellular histones on erythrocyte function. We demonstrate here that histones promote erythrocyte aggregation, sedimentation and, using a novel in vitro shear stress model, induce erythrocyte...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/218034
Source: Blood
DOI: 10.1182/blood-2017-06-790519

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