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Engineering Highly Interconnected Neuronal Networks on Nanowire Scaffolds

Gautam, Vini; Naureen, Shagufta; Shahid, Naeem; Gao, Qian; Wang, Yi; Nisbet, David; Jagadish, Chennupati; Daria, Vincent

Description

Identifying the specific role of physical guidance cues in the growth of neurons is crucial for understanding the fundamental biology of brain development and for designing scaffolds for tissue engineering. Here, we investigate the structural significance of nanoscale topographies as physical cues for neurite outgrowth and circuit formation by growing neurons on semiconductor nanowires. We monitored neurite growth using optical and scanning electron microscopy and evaluated the spontaneous...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/218012
Source: Nano Letters
DOI: 10.1021/acs.nanolett.6b05288

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