DOCK8 drives Src-dependent NK Cell effector function
Kearney, Connor J; Vervoort, Stephin J.; Ramsbottom, Kelly M.; Freeman, Andrew J.; Michie, Jessica; Peake, J.M; Casanova, Jean-Laurent; Picard, Capucine; Tangye, Stuart G; Ma, Cindy S.; Johnstone, Ricky; Randall, Katrina; Oliaro, Jane
Mutations in the dedicator of cytokinesis 8 (DOCK8) gene cause an autosomal recessive form of hyper-IgE syndrome, characterized by chronic immunodeficiency with persistent microbial infection and increased incidence of malignancy. These manifestations suggest a defect in cytotoxic lymphocyte function and immune surveillance. However, how DOCK8 regulates NK cell–driven immune responses remains unclear. In this article, we demonstrate that DOCK8 regulates NK cell cytotoxicity and cytokine...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Immunology|
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