Skip navigation
Skip navigation

DOCK8 drives Src-dependent NK Cell effector function

Kearney, Connor J; Vervoort, Stephin J.; Ramsbottom, Kelly M.; Freeman, Andrew J.; Michie, Jessica; Peake, J.M; Casanova, Jean-Laurent; Picard, Capucine; Tangye, Stuart G; Ma, Cindy S.; Johnstone, Ricky; Randall, Katrina; Oliaro, Jane


Mutations in the dedicator of cytokinesis 8 (DOCK8) gene cause an autosomal recessive form of hyper-IgE syndrome, characterized by chronic immunodeficiency with persistent microbial infection and increased incidence of malignancy. These manifestations suggest a defect in cytotoxic lymphocyte function and immune surveillance. However, how DOCK8 regulates NK cell–driven immune responses remains unclear. In this article, we demonstrate that DOCK8 regulates NK cell cytotoxicity and cytokine...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Journal of Immunology
DOI: 10.4049/jimmunol.1700751


There are no files associated with this item.

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  17 November 2022/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator