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B cell-extrinsic Myd88 and Fcer1g negatively regulate autoreactive and normal B cell immune responses

Sweet, Rebecca; Nickerson, Kevin M; Cullen, J; Wang, Yujuan; Shlomchik, M J

Description

MyD88 and FcR common γ-chain (Fcer1g, FcRγ) elicit proinflammatory responses to exogenous Ags. Deletion of these receptors in autoimmune models has generally led to reduced overall disease. In B cells, Myd88 is required for anti-DNA and anti-RNA autoantibody responses, whereas Fcer1g is not expressed in these cells. The roles of these receptors in myeloid cells during B cell autoimmune activation remain less clear. To investigate the roles of Myd88 and Fcer1g in non-B cells, we transferred...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/217872
Source: Journal of Immunology
DOI: 10.4049/jimmunol.1600861

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