A Unified Approach to the Isomeric α‑, β‑, γ‑, and δ-Carbolines via their 6,7,8,9-Tetrahydro Counterparts
A cross-coupling/reductive cyclization protocol has been employed in a unified approach to all four carbolines. So, for example, the 2-nitropyridine 8, which is readily prepared through an efficient palladium-catalyzed Ullmann cross-coupling reaction, is reductively cyclized under conventional conditions to give 6,7,8,9-tetrahydro-α-carboline that is itself readily aromatized to give α carboline (1).
|Collections||ANU Research Publications|
|Source:||Journal of Organic Chemistry|
|Access Rights:||Open Access|
|A Unified Approach to the Carbolines and Their Tetrahydro-Counterparts R1.pdf||394.27 kB||Adobe PDF|
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