Population-Level Human Secretor Status Is Associated With Genogroup 2 Type 4 Norovirus Predominance
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Arrouzet, Cory J.; Ellis, Karen; Kambhampati, Anita; Chen, Yingxi; Steele, Molly; Lopman, Ben
Description
Background. Noroviruses are a leading cause of acute gastroenteritis. Genogroup 2 type 4 (GII.4) has been the dominant norovirus genotype worldwide since its emergence in the mid-1990s. Individuals with a functional fucosyltransferase-2 gene, known as secretors, have increased susceptibility to GII.4 noroviruses. We hypothesized that this individual-level trait may drive GII.4 norovirus predominance at the human population level. Methods. We conducted a systematic review for studies reporting...[Show more]
Collections | ANU Research Publications |
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Date published: | 2020-01-04 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/217383 |
Source: | Journal of Infectious Diseases |
DOI: | 10.1093/infdis/jiz693 |
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01_Arrouzet_Population-Level_Human_2020.pdf | 11.93 MB | Adobe PDF |
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