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Population-Level Human Secretor Status Is Associated With Genogroup 2 Type 4 Norovirus Predominance

Arrouzet, Cory J.; Ellis, Karen; Kambhampati, Anita; Chen, Yingxi; Steele, Molly; Lopman, Ben


Background. Noroviruses are a leading cause of acute gastroenteritis. Genogroup 2 type 4 (GII.4) has been the dominant norovirus genotype worldwide since its emergence in the mid-1990s. Individuals with a functional fucosyltransferase-2 gene, known as secretors, have increased susceptibility to GII.4 noroviruses. We hypothesized that this individual-level trait may drive GII.4 norovirus predominance at the human population level. Methods. We conducted a systematic review for studies reporting...[Show more]

CollectionsANU Research Publications
Date published: 2020-01-04
Type: Journal article
Source: Journal of Infectious Diseases
DOI: 10.1093/infdis/jiz693


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