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Role of apolipoprotein E epsilon 4 (APOE*epsilon 4) as an independent risk factor for incident depression over a 12-year period in cognitively intact adults across the lifespan

Burns, Richard; Andrews, Shea; Cherbuin, Nicolas; Anstey, Kaarin


Background The apolipoprotein E ε4 allele (APOE*ε4) is indicated as a risk for Alzheimer's disease and other age-related diseases. The risk attributable to APOE*ε4 for depression is less clear and may be because of confounding of the relationship between dementia and depression. Aims We examined the risk of APOE* ε4 for incident depression and depressive symptomology over a 12-year period across the adult lifespan. Method Participants were from the Personality and Total Health Through Life...[Show more]

CollectionsANU Research Publications
Date published: 2020-05-08
Type: Journal article
Source: British Journal of Psychiatry Open
DOI: 10.1192/bjo.2020.29
Access Rights: Open Access


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