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Structural brain changes with lifetime trauma and re-experiencing symptoms is 5-HTTLPR genotype-dependent

Ancelin, Marie-Laure; Carriere, Isabelle; Artero, Sylvaine; Maller, Jerome; Meslin, Chantal; Dupuy, Marie; Ritchie, K; Ryan, Joanne; Chaudieu, Isabelle


Background: Findings on structural brain alterations following trauma are inconsistent due probably to heterogeneity in imaging studies and population, clinical presentations, genetic vulnerability, and selection of controls. This study examines whether trauma and reexperiencing symptoms are associated with specific alterations in grey matter volumes and if this varies according to 5-HTTLPR genotype. Methods: Structural MRI was used to acquire anatomical scans from 377 communitydwelling...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
Source: European Journal of Psychotraumatology
DOI: 10.1080/20008198.2020.1733247
Access Rights: Open Access


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