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Galanin receptor-1 knockout mice exhibit spontaneous epilepsy, abnormal EEG's and altered inhibition in the hippocampus

McColl, Craig; Jacoby, Arie S; Shine, John; Iismaa, Tiina P; Bekkers, John


Galanin is a widely-distributed neuropeptide that acts as an endogenous anticonvulsant. We have recently generated a galanin receptor type 1 knockout mouse (Galr1-/-) that develops spontaneous seizures. Our aim here was to characterize the seizures by making electroencephalogram (EEG) recordings from this animal, and also to elucidate the cellular basis of its epileptic phenotype by studying the neurophysiology of CA1 pyramidal neurons in acute hippocampal slices. EEGs showed that major...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Neuropharmacology
DOI: 10.1016/j.neuropharm.2005.09.001


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