Prognostic efficacy of cardiac biomarkers for mortality in dialysis patients
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Hickman, Peter; McGill, Darryl; Talaulikar, Girish; Hiremagalur, Balaji; Bromley, Jonathan; Rahman, A; Koerbin, Gus; Southcott, Emma K; Potter, Julia
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Background: The high prevalence of cardiovascular mortality in the end-stage renal disease population is well established. The aim of this current study was to document the relative prognostic significance of established cardiac biomarkers troponin T (TnT), troponin I (TnI), B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-pro-BNP) in this population. Methods: A prospective cohort study of dialysis patients undertaken in a single tertiary centre in Australia. Relevant clinical and...[Show more]
dc.contributor.author | Hickman, Peter | |
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dc.contributor.author | McGill, Darryl | |
dc.contributor.author | Talaulikar, Girish | |
dc.contributor.author | Hiremagalur, Balaji | |
dc.contributor.author | Bromley, Jonathan | |
dc.contributor.author | Rahman, A | |
dc.contributor.author | Koerbin, Gus | |
dc.contributor.author | Southcott, Emma K | |
dc.contributor.author | Potter, Julia | |
dc.date.accessioned | 2015-12-07T22:27:01Z | |
dc.identifier.issn | 1444-0903 | |
dc.identifier.uri | http://hdl.handle.net/1885/21706 | |
dc.description.abstract | Background: The high prevalence of cardiovascular mortality in the end-stage renal disease population is well established. The aim of this current study was to document the relative prognostic significance of established cardiac biomarkers troponin T (TnT), troponin I (TnI), B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-pro-BNP) in this population. Methods: A prospective cohort study of dialysis patients undertaken in a single tertiary centre in Australia. Relevant clinical and biochemical information was collected at entry and all patients followed up prospectively without any loss to follow up. End-point of interest was all-cause mortality. Statistical analysis using Cox proportional hazards was used to study relationship between competing covariates and outcome. A total of 143 patients with a mean age of 59.67 ± 15.49 years was followed up for a median duration of 30 months. Of these patients, 89.3% were white Australians of European ancestry. Twenty-seven per cent had an established diagnosis of diabetes mellitus. The mean concentrations (±SD) of TnT, TnI, BNP and N-terminal peptide pro-BNP (NT-pro-BNP) were 0.08 ± 0.04g/L, 0.09 ± 0.2g/L, 270 ± 117 ng/L and 1434 ± 591 ng/L respectively. Results: Twenty-eight subjects died during the period of follow up. By univariate analysis, all cardiac markers (TnT, TnI, BNP, NT-pro-BNP and C-reactive protein) were significantly associated with an increase in mortality. On Cox proportionate hazards analysis, only albumin and NT-pro-BNP showed a significant association with mortality, with hazard ratios of 0.834, 95% confidence interval (CI) 0.779-0.893, P < 0.001, and 1.585, 95%CI 1.160-20165, P = 0.004 respectively. Conclusion: In patients with end-stage renal failure on dialysis NT-pro-BNP provides greater prognostic information compared with TnT and TnI. | |
dc.publisher | Blackwell Science Asia | |
dc.source | Internal Medicine Journal | |
dc.subject | Keywords: albumin; amino terminal pro brain natriuretic peptide; biological marker; brain natriuretic peptide; C reactive protein; cholesterol; triacylglycerol; troponin I; troponin T; adult; aged; albumin blood level; article; Australia; cholesterol blood level; c BNP; Dialysis; Mortality; NT-pro-BNP; Renal failure; Troponin | |
dc.title | Prognostic efficacy of cardiac biomarkers for mortality in dialysis patients | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 39 | |
dc.date.issued | 2009 | |
local.identifier.absfor | 110201 - Cardiology (incl. Cardiovascular Diseases) | |
local.identifier.ariespublication | u4201517xPUB18 | |
local.type.status | Published Version | |
local.contributor.affiliation | Hickman, Peter, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | McGill, Darryl, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Talaulikar, Girish, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Hiremagalur, Balaji, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Bromley, Jonathan, Canberra Hospital | |
local.contributor.affiliation | Rahman, A, The Canberra Hospital | |
local.contributor.affiliation | Koerbin, Gus, ACT Health | |
local.contributor.affiliation | Southcott, Emma K, The Canberra Hospital | |
local.contributor.affiliation | Potter, Julia, College of Medicine, Biology and Environment, ANU | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.startpage | 812 | |
local.bibliographicCitation.lastpage | 818 | |
local.identifier.doi | 10.1111/j.1445-5994.2009.01846.x | |
dc.date.updated | 2016-02-24T10:41:10Z | |
local.identifier.scopusID | 2-s2.0-73649137519 | |
Collections | ANU Research Publications |
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