Sharkhuu, Tuya; Matthaei, Klaus; Forbes, Elizabeth; Mahalingam, Suresh (Surendran); Hogan, Simon P; Hansbro, Phil M; Foster, Paul S
Background: IL-25, a novel member of the IL-17 cytokine family, promotes CD4+ T-helper 2 lymphocyte-like (Th type-2) inflammatory responses in the lung. Although IL-25 up-regulates IL-13 in the lung, the contribution of this and other type 2 cytokine signalling pathways to the induction and persistence of airways hyper-reactivity (AHR) and allergic inflammation are unclear. Objective: To determine the downstream factors employed by IL-25 to induce Th type-2 pulmonary inflammation and AHR....[Show more]
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