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Gene expression differences between Crohn's disease aphthous ulcers and healthy Peyer's patches highlight novel therapeutic targets

O'Brien, Claire; Patel, Hardip; Freeman, T; Zhang, Kerong; Peng, Kaiman; Virgin, H W; Zhao, G; Pavli, Paul


Background and Aim: The earliest macroscopic lesion in Crohn’s disease(CD) is the aphthous ulcer, which overlies Peyer’s patches and lymphoidfollicles. Our aim was to characterize differences in gene expression andthe virome of aphthous ulcers and Peyer’s patches.Methods: Biopsies (n = 24) were obtained from the terminal ileum of 12patients (six with CD and six healthy controls). Aphthous ulcers and adja-cent unaffected mucosa were obtained from patients with CD, and Peyer’spatches and adjacent...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Conference paper
Source: Journal of Gastroenterology and Hepatology
DOI: 10.1111/jgh.13894
Access Rights: Open Access via publisher website


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