RNA Polymerase I Transcription Inhibition: A novel therapeutic strategy for osteosarcoma
Osteosarcoma (OS) is the most commonly occurring primary bone cancer in the young. A combination of surgery and chemotherapy is the most effective therapeutic strategy, however, the survival rate for patients with metastatic disease is less than 20% at 5 years, a statistic that has not changed for over 30 years. To support the rapid cell growth and proliferation that are characteristic of cancer cells, the rate of ribosome biogenesis must increase, and the transcriptional activity of RNA...[Show more]
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