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Lifetime major depression and grey-matter volume

Ancelin, Marie-Laure; Carrière, Isabelle; Artero, Sylvaine; Maller, Jerome; Meslin, Chantal; Ritchie, Karen; Ryan, Joanne; Chaudieu, Isabelle


Background: There is evidence of structural brain alterations in major depressive disorder (MDD), but little is known about how these alterations might be affected by age at onset or genetic vulnerability. This study examines whether lifetime episodes of MDD are associated with specific alterations in grey-matter volume, and whether those alterations vary according to sex or serotonin transporter-linked promoter region (5-HTTLPR) genotype (LL, SL or SS). Methods: We used structural MRI to...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: Journal of Psychiatry and Neuroscience
DOI: 10.1503/jpn.180026


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