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Heparanase and Type 1 Diabetes

Simeonovic, Charmaine; Popp, Sarah; Brown, Deborah; Li, Fei-Ju; Lafferty, Antony; Freeman, Craig; Parish, Christopher


Type 1 diabetes (T1D) results from autoimmune destruction of insulin-producing beta cells in pancreatic islets. The degradation of the glycosaminoglycan heparan sulfate (HS) by the endo-β-D-glycosidase heparanase plays a critical role in multiple stages of the disease process. Heparanase aids (i) migration of inflammatory leukocytes from the vasculature to the islets, (ii) intra-islet invasion by insulitis leukocytes, and (iii) selective destruction of beta cells. These disease stages are...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Book chapter
DOI: 10.1007/978-3-030-34521-1_24


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