Skip navigation
Skip navigation

The cytoskeletal motor proteins Dynein and MyoV direct apical transport of Crumbs

Aguilar-Aragon, Mario; Fletcher, Georgina; Thompson, Barry

Description

Crumbs (Crb in Drosophila; CRB1-3 in mammals) is a transmembrane determinant of epithelial cell polarity and a regulator of Hippo signalling. Crb is normally localized to apical cell-cell contacts, just above adherens junctions, but how apical trafficking of Crb is regulated in epithelial cells remains unclear. We use the Drosophila follicular epithelium to demonstrate that polarized trafficking of Crb is mediated by transport along microtubules by the motor protein Dynein and along actin...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
URI: http://hdl.handle.net/1885/216201
Source: Developmental Biology
DOI: 10.1016/j.ydbio.2019.12.009
Access Rights: Open Access

Download

File Description SizeFormat Image
01_Aguilar-Aragon_The_cytoskeletal_motor_2020.pdf5.79 MBAdobe PDFThumbnail


This item is licensed under a Creative Commons License Creative Commons

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator