Aspirin Prevents and Partially Reverses Adrenocorticotropic Hormone-Induced Hypertension in the Rat
Background: Glucocorticoid-induced hypertension is associated with increased oxidative stress. The aim of the present study was to investigate the effects of aspirin, a potent antioxidant, on adrenocorticotropic hormone (ACTH) and dexamethasone (Dex)-induced hypertension. Methods: Male Sprague-Dawley (SD) rats were treated with saline, ACTH (0.2 mg/kg/d subcutaneously) or Dex (10 μg/rat/d subcutaneously). Aspirin (100 mg/kg/d in drinking water) was given 4 days before and during...[Show more]
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|Source:||American Journal of Hypertension|
|01_Zhang_Aspirin_Prevents_and_Partially_2007.pdf||395.39 kB||Adobe PDF||Request a copy|
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