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Aspirin Prevents and Partially Reverses Adrenocorticotropic Hormone-Induced Hypertension in the Rat

Zhang, Yi; Miao, Yuchun; Whitworth, Judith


Background: Glucocorticoid-induced hypertension is associated with increased oxidative stress. The aim of the present study was to investigate the effects of aspirin, a potent antioxidant, on adrenocorticotropic hormone (ACTH) and dexamethasone (Dex)-induced hypertension. Methods: Male Sprague-Dawley (SD) rats were treated with saline, ACTH (0.2 mg/kg/d subcutaneously) or Dex (10 μg/rat/d subcutaneously). Aspirin (100 mg/kg/d in drinking water) was given 4 days before and during...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: American Journal of Hypertension
DOI: 10.1016/j.amjhyper.2007.07.009


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