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Lactic Acidosis Together with GM-CSF and M-CSF Induces Human Macrophages toward an Inflammatory Protumor Phenotype

Paolini, Lea; Adam, Clement; Beauvillain, Celine; Preisser, Laurence; Blanchard, Simon; Pignon, Pascale; Seegers, Valerie; Chevalier, Louise-Marie; Campone, Mario; Wernert, Romuald; Verrielle, Veronique; Raro, Pedro; Ifrah, Norbert; Lavoue, Vincent; Descamps, Philippe; Morel, Alain; Catros, Veronique; Tcherkez, Guillaume; Lenaers, Guy; Bocca, Cinzia; Nzoughet, Judith Kouassi; Procaccio, Vincent; Delneste, Yves; Jeannin, Pascale


In established tumors, tumor-associated macrophages (TAM) orchestrate nonresolving cancer-related inflammation and produce mediators favoring tumor growth, metastasis, and angiogenesis. However, the factors conferring inflammatory and protumor properties on human macrophages remain largely unknown. Most solid tumors have high lactate content. We therefore analyzed the impact of lactate on human monocyte differentiation. We report that prolonged lactic acidosis induces the differentiation...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
Source: Cancer Immunology Research
DOI: 10.1158/2326-6066.CIR-18-0749


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