Shcheglovitov, Aleksandr; Vitko, Iuliia; Bidaud, Isabelle; Baumgart, Joel P; Navarro-Gonzalez, Manuel; Grayson, Thomas; Lory, Philippe; Hill, Caryl; Perez-Reyes, Edward
Molecular diversity of T-type/Cav3 Ca2+ channels is created by expression of three genes and alternative splicing of those genes. Prompted by the important role of the I-II linker in gating and surface expression of Cav3 channels, we describe here the properties of a novel variant that partially deletes this loop. The variant is abundantly expressed in rat brain, even exceeding transcripts with the complete exon 8. Electrophysiological analysis of the Δ8b variant revealed enhanced current...[Show more]
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