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Alternative splicing within the I-II loop controls surface expression of T-type Ca(v)3.1 calcium channels

Shcheglovitov, Aleksandr; Vitko, Iuliia; Bidaud, Isabelle; Baumgart, Joel P; Navarro-Gonzalez, Manuel; Grayson, Thomas; Lory, Philippe; Hill, Caryl; Perez-Reyes, Edward


Molecular diversity of T-type/Cav3 Ca2+ channels is created by expression of three genes and alternative splicing of those genes. Prompted by the important role of the I-II linker in gating and surface expression of Cav3 channels, we describe here the properties of a novel variant that partially deletes this loop. The variant is abundantly expressed in rat brain, even exceeding transcripts with the complete exon 8. Electrophysiological analysis of the Δ8b variant revealed enhanced current...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: FEBS Letters
DOI: 10.1016/j.febslet.2008.10.013


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