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Environmental Risk Factors for Multiple Sclerosis: A Review with a Focus on Molecular Mechanisms

O'Gorman, Cullen; Taylor, Bruce V; Lucas, Robyn


Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system commonly affecting young adults. Pathologically, there are patches of inflammation (plaques) with demyelination of axons and oligodendrocyte loss. There is a global latitude gradient in MS prevalence, and incidence of MS is increasing (particularly in females). These changes suggest a major role for environmental factors in causation of disease. We have reviewed the evidence and potential mechanisms of action...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: International Journal of Molecular Sciences
DOI: 10.3390/ijms130911718


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