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Regulation of MicroRNA by Antagomirs: A New Class of Pharmacological Antagonists for the Specific Regulation of Gene Function?

Mattes, Joerg; Yang, Ming; Foster, Paul S


The discovery of small "noncoding" or "nonmessenger" RNA molecules that are repressors of translation (microRNAs) has provided the opportunity to specifically suppress a gene or clusters of genes. Moreover, the recent employment of synthetic analogs of these small RNA molecules termed "antagomirs" has shown that microRNAs of interest can be specifically targeted. Understanding the role of microRNAs in fundamental processes associated with complex diseases such as asthma, chronic obstructive...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: American Journal of Respiratory Cell and Molecular Biology
DOI: 10.1165/rcmb.2006-0227TR


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