Binuclear Metallohydrolases: Complex Mechanistic Strategies for a Simple Chemical Reaction
Binuclear metallohydrolases are a large family of enzymes that require two closely spaced transition metal ions to carry out a plethora of hydrolytic reactions. Representatives include purple acid phosphatases (PAPs), enzymes that play a role in bone metabolism and are the only member of this family with a heterovalent binuclear center in the active form (Fe3+-M2+, M = Fe, Zn, Mn). Other members of this family are urease, which contains a di-Ni2+ center and catalyzes the breakdown of urea,...[Show more]
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