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Tumor Necrosis Factor-Induced Cerebral Insulin Resistance in Alzheimer's Disease Links Numerous Treatment Rationales

Clark, Ian A; Atwood, Craig S.; Bowen, Richard; Da Paz Filho, Gilberto; Vissel, Bryce


The evident limitations of the amyloid theory of the pathogenesis of Alzheimer's disease are increasingly putting alternatives in the spotlight. We argue here that a number of independently developing approaches to therapy-including specific and nonspecific anti-tumor necrosis factor (TNF) agents, apolipoprotein E mimetics, leptin, intranasal insulin, the glucagon-like peptide-1 mimetics and glycogen synthase kinase-3 (GSK-3) antagonists-are all part of an interlocking chain of events. All...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Pharmacological Reviews
DOI: 10.1124/pr.112.005850


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