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Learning rules for spike timing-dependent plasticity depend on dendritic synapse location

Letzkus, Johannes; Kampa, Bjoern; Stuart, Gregory J

Description

Previous studies focusing on the temporal rules governing changes in synaptic strength during spike timing-dependent synaptic plasticity (STDP) have paid little attention to the fact that synaptic inputs are distributed across complex dendritic trees. During STDP, propagation of action potentials (APs) back to the site of synaptic input is thought to trigger plasticity. However, in pyramidal neurons, backpropagation of single APs is decremental, whereas high-frequency bursts lead to generation...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
URI: http://hdl.handle.net/1885/21282
Source: Journal of Neuroscience
DOI: 10.1523/JNEUROSCI.2650-06.2006

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