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Renal Glomeruli and Tubular Injury Following Indomethacin, Ibuprofen, and Gentamicin Exposure in a Neonatal Rat Model

Kent, Alison; Maxwell, Lesley; Konia, Mark E; Falk, Michael; Willenborg, David; Dahlstrom, Jane


Indomethacin, ibuprofen, and gentamicin are commonly administered to neonates between 24 and 28 wk gestation when glomerulogenesis is still occurring. Indomethacin is known to cause renal failure in up to 25% of infants treated. Possible morphologic effects of these drugs are largely unknown. The purpose of this study was to determine the type of renal changes found on light (LM) and electron microscopy (EM) following administration of indomethacin, ibuprofen, and gentamicin in a neonatal rat...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Pediatric Research
DOI: 10.1203/PDR.0b013e318123f6e3


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