de Villiers, Marianne; Spry, Christina; Macuamule, Cristiano; Barnard, Leanne; Wells, Gordon; Saliba, Kevin; Strauss, Erick
N-Substituted pantothenamides (PanAms) are pantothenate analogues with up to nanomolar potency against blood-stage Plasmodium falciparum (the most virulent species responsible for malaria). Although these compounds are known to target coenzyme A (CoA) biosynthesis and/or utilization, their exact mode of action (MoA) is still unknown. Importantly, PanAms that retain the natural β-alanine moiety are more potent than other variants, consistent with the involvement of processes that are selective...[Show more]
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