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A chemoenzymatic and enantioselective total synthesis of the resorcylic acid lactone L-783,290, the trans -isomer of L-783,277

Lin, Andrew; Willis, Anthony; Banwell, Martin

Description

The structure, 5, assigned to the resorcylic acid lactone L-783,290 has been prepared for the first time and in a modular fashion using a Heck reaction to link the readily available fragments 8 and 14. Chemoenzymatic methods were used to prepare the latter fragment, in enantiopure form, from chlorobenzene.

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/21208
Source: Tetrahedron Letters
DOI: 10.1016/j.tetlet.2009.12.067

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