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Decreased Threshold for the Nitric Oxide Donor Glyceryl Trinitrate in Cortisol-Induced Hypertension in Humans

Kelly, John J; Tam, Sim Hom; Williamson, Paula M; Whitworth, Judith


1. Decreased nitric oxide (NO) availability is thought to be a feature of cortisol-induced hypertension in humans. 2. We hypothesized that, accordingly, the threshold for a depressor response to NO should be decreased by cortisol treatment. 3. We re-analysed data from a study of baroreflex function in normal men treated with cortisol using glyceryl trinitrate (GTN). 4. Cortisol treatment increased blood pressure and decreased the threshold dose of GTN for a fall in systolic and mean blood...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Clinical and Experimental Pharmacology and Physiology
DOI: 10.1111/j.1440-1681.2007.04700.x


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