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Consensus Mutagenesis and Ancestral Reconstruction Provide Insight into the Substrate Specificity and Evolution of the Front-End 6-Desaturase Family

Li, Dongdi; Damry, Adam; Petrie, James; Vanhercke, Thomas; Singh, Surinder; Jackson, Colin


Marine algae are a major source of ω-3 long-chain polyunsaturated fatty acids (ω3-LCPUFAs), which are conditionally essential nutrients in humans and a target for industrial production. The biosynthesis of these molecules in marine algae requires the desaturation of fatty acids by Δ6-desaturases, and enzymes from different species display a range of specificities toward ω3- and ω6-LCPUFA precursors. In the absence of a molecular structure, the structural basis for the variable substrate...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
Source: Biochemistry
DOI: 10.1021/acs.biochem.0c00110


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