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Extrafollicular antibody responses

MacLennan, Ian CM; Toellner, K-M; Cunningham, Adam F; Serre, Karine; Sze, Daniel M-Y; Zuniga, Elina; Cook, Matthew; Garcia De Vinuesa, Maria Carola


In adaptive antibody responses, B cells are induced to grow either in follicles where they form germinal centers or in extrafollicular foci as plasmablasts. Extrafollicular growth typically occurs in the medullary cords of lymph nodes and in foci in the red pulp of the spleen. It is not a feature of secondary lymphoid tissue associated with the internal epithelia of the body. All types of naïve and memory B cells can be recruited into extrafollicular responses. These responses are associated...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Immunological Reviews
DOI: 10.1034/j.1600-065X.2003.00058.x


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