Shishmarev, Dmitry; Quiquempoix, Lucas; Fontenelle, Clement Q; Linclau, Bruno; Kuchel, Philip William
Five 19F-substituted glucose analogues were used to probe the activity and mechanism of the enzyme mutarotase by using magnetisation-exchange NMR spectroscopy. The sugars (2-fluoro-2-deoxy-D-glucose, FDG2; 3-fluoro-3-deoxyD-glucose,
FDG3; 4-fluoro-4-deoxy-D-glucose, FDG4; 2,3-difluoro-2,3-dideoxy-D-glucose, FDG23; and 2,2,3,3-tetrafluoro-2,3-dideoxy-D-glucose (2,3-dideoxy-2,2,3,3-tetrafluoro-D-erythro-hexopyranose), FDG2233) showed separate 19F NMR spectroscopic resonances from their...[Show more]
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