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A functional genetic screen defines the AKT-induced senescence signaling network

Chan, Keefe; Blake, Shaun; Zhu, Haoran; Kang, Jian; Trigos, Anna S.; Madhamshettiwar, Piyush; Diesch, Jeannine; Paavolainen, Lassi; Horvath, Peter; Hannan, Ross; George, Amee; Sanij, Elaine; Hannan, Kate; Simpson, Kaylene J.; Pearson, Richard B


Exquisite regulation of PI3K/AKT/mTORC1 signaling is essential for homeostatic control of cell growth, proliferation, and survival. Aberrant activation of this signaling network is an early driver of many sporadic human cancers. Paradoxically, sustained hyperactivation of the PI3K/AKT/mTORC1 pathway in nontransformed cells results in cellular senescence, which is a tumor-suppressive mechanism that must be overcome to promote malignant transformation. While oncogene-induced senescence (OIS)...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
Source: Cell Death and Differentiation
DOI: 10.1038/s41418-019-0384-8
Access Rights: Open Access


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